Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples.
نویسندگان
چکیده
We report a sensitive method for selective detection of target metabolites from the central metabolic pathway by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), in which the MS signal is enhanced by up to three orders of magnitude in the course of in situ enzymatic amplification.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 46 13 شماره
صفحات -
تاریخ انتشار 2010